View : 30 Download: 0

Effects of capsaicin on lipid catabolism in 3T3-L1 adipocytes

Title
Effects of capsaicin on lipid catabolism in 3T3-L1 adipocytes
Authors
Lee M.-S.Kim C.-T.Kim I.-H.Kim Y.
Ewha Authors
김양하
SCOPUS Author ID
김양하scopus
Issue Date
2011
Journal Title
Phytotherapy Research
ISSN
0951-418XJCR Link
Citation
vol. 25, no. 6, pp. 935 - 939
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a pungent ingredient of red peppers, and has been reported to reduce body weight gain and adiposity in rodents. The present study investigated the effects of capsaicin on lipid catabolism in differentiated 3T3-L1 adipocytes. Capsaicin decreased the intracellular lipid content in a concentration-dependent manner. The release of glycerol into the medium was increased by the addition of capsaicin. The mRNA levels of genes involved in lipid catabolism such as hormone sensitive lipase (HSL), carnitine palmitoyl transferase-Iα (CPTI-α) and uncoupling protein 2 (UCP2) were up-regulated significantly. These results suggest that capsaicin exerts its lipolytic action by increasing the hydrolysis of triacylglycerol in adipocytes, and that these effects are mediated at least partially by regulation of the expression of multiple genes that are involved in the lipid catabolic pathway, such as HSL and CPT-Iα, and those involved in thermogenesis such as UCP2. Copyright © 2010 John Wiley & Sons, Ltd.
DOI
10.1002/ptr.3339
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE