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Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src

Title
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
Authors
Jung J.Kim H.Y.Kim M.Sohn K.Lee K.
Ewha Authors
이경림
SCOPUS Author ID
이경림scopus
Issue Date
2011
Journal Title
Oncogene
ISSN
0950-9232JCR Link
Citation
vol. 30, no. 19, pp. 2264 - 2274
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Translationally controlled tumor protein (TCTP) is implicated in cell growth and malignant transformation. TCTP has been found to interact directly with the third cytoplasmic domain of the α subunit of Na,K-ATPase, but whether this interaction has a role in tumorigenesis is unclear. In this study, we examined TCTP-induced tumor progression signaling networks in human breast epithelial cells, using adenoviral infection. We found that TCTP (a) induces Src release from Na,K-ATPase α subunit and Src activation; (b) phosphorylates tyrosine residues 845, 992, 1086, 1148 and 1173 on anti-epidermal growth factor receptor (EGFR); (c) activates PI3K (phosphatidylinositol 3-kinase)-AKT, Ras-Raf-MEK-ERK1/2, Rac-PAK1/2, MKK3/6-p38 and phospholipase C (PLC)-γ pathways; (d) enhances NADPH oxidase-dependent reactive oxygen species (ROS) generation; (e) stimulates cytoskeletal remodeling and cell motility and (f) upregulates matrix metalloproteinase (MMP) 3 and 13. These findings suggest that TCTP induces tumorigenesis through distinct multicellular signaling pathways involving Src-dependent EGFR transactivation, ROS generation and MMP expression. © 2011 Macmillan Publishers Limited All rights reserved.
DOI
10.1038/onc.2010.604
Appears in Collections:
약학대학 > 약학과 > Journal papers
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