Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이경림 | * |
dc.date.accessioned | 2016-08-28T12:08:43Z | - |
dc.date.available | 2016-08-28T12:08:43Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0950-9232 | * |
dc.identifier.other | OAK-7614 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221653 | - |
dc.description.abstract | Translationally controlled tumor protein (TCTP) is implicated in cell growth and malignant transformation. TCTP has been found to interact directly with the third cytoplasmic domain of the α subunit of Na,K-ATPase, but whether this interaction has a role in tumorigenesis is unclear. In this study, we examined TCTP-induced tumor progression signaling networks in human breast epithelial cells, using adenoviral infection. We found that TCTP (a) induces Src release from Na,K-ATPase α subunit and Src activation; (b) phosphorylates tyrosine residues 845, 992, 1086, 1148 and 1173 on anti-epidermal growth factor receptor (EGFR); (c) activates PI3K (phosphatidylinositol 3-kinase)-AKT, Ras-Raf-MEK-ERK1/2, Rac-PAK1/2, MKK3/6-p38 and phospholipase C (PLC)-γ pathways; (d) enhances NADPH oxidase-dependent reactive oxygen species (ROS) generation; (e) stimulates cytoskeletal remodeling and cell motility and (f) upregulates matrix metalloproteinase (MMP) 3 and 13. These findings suggest that TCTP induces tumorigenesis through distinct multicellular signaling pathways involving Src-dependent EGFR transactivation, ROS generation and MMP expression. © 2011 Macmillan Publishers Limited All rights reserved. | * |
dc.language | English | * |
dc.title | Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src | * |
dc.type | Article | * |
dc.relation.issue | 19 | * |
dc.relation.volume | 30 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2264 | * |
dc.relation.lastpage | 2274 | * |
dc.relation.journaltitle | Oncogene | * |
dc.identifier.doi | 10.1038/onc.2010.604 | * |
dc.identifier.wosid | WOS:000290514600009 | * |
dc.identifier.scopusid | 2-s2.0-79955863530 | * |
dc.author.google | Jung J. | * |
dc.author.google | Kim H.Y. | * |
dc.author.google | Kim M. | * |
dc.author.google | Sohn K. | * |
dc.author.google | Lee K. | * |
dc.contributor.scopusid | 이경림(7501517435) | * |
dc.date.modifydate | 20240301081003 | * |