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Cell-penetrating chitosan/doxorubicin/TAT conjugates for efficient cancer therapy

Title
Cell-penetrating chitosan/doxorubicin/TAT conjugates for efficient cancer therapy
Authors
Lee J.-Y.Choi Y.-S.Suh J.-S.Kwon Y.-M.Yang V.C.Lee S.-J.Chung C.-P.Park Y.-J.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2011
Journal Title
International Journal of Cancer
ISSN
0020-7136JCR Link
Citation
vol. 128, no. 10, pp. 2470 - 2480
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In this study, a cell-penetrating peptide, the transactivating transcriptional factor (TAT) domain from HIV, was linked to a chitosan/doxorubicin (chitosan/DOX) conjugate to form a chitosan/DOX/TAT hybrid. The synthesized chitosan/DOX/TAT conjugate showed a different intracellular distribution pattern from a conjugate without TAT. Unlike both free DOX and the conjugate without TAT, the chitosan/DOX/TAT conjugate was capable of efficient cell entry. The chitosan/DOX/TAT conjugate was found to be highly cytotoxic, with an IC50 value of approximately 480 nM, 2 times less than that of chitosan/DOX (980 nM). The chitosan/DOX/TAT provided decreases in tumor volume of 77.4 and 57.5% compared to free DOX and chitosan/DOX, respectively, in tumor-bearing mice. Therefore, this study suggests that TAT-mediated chitosan/DOX conjugate delivery is effective in slowing tumor growth. Copyright © 2010 UICC.
DOI
10.1002/ijc.25578
Appears in Collections:
약학대학 > 약학과 > Journal papers
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