Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2016-08-28T12:08:27Z | - |
dc.date.available | 2016-08-28T12:08:27Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.other | OAK-7452 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221518 | - |
dc.description.abstract | In this study, a cell-penetrating peptide, the transactivating transcriptional factor (TAT) domain from HIV, was linked to a chitosan/doxorubicin (chitosan/DOX) conjugate to form a chitosan/DOX/TAT hybrid. The synthesized chitosan/DOX/TAT conjugate showed a different intracellular distribution pattern from a conjugate without TAT. Unlike both free DOX and the conjugate without TAT, the chitosan/DOX/TAT conjugate was capable of efficient cell entry. The chitosan/DOX/TAT conjugate was found to be highly cytotoxic, with an IC50 value of approximately 480 nM, 2 times less than that of chitosan/DOX (980 nM). The chitosan/DOX/TAT provided decreases in tumor volume of 77.4 and 57.5% compared to free DOX and chitosan/DOX, respectively, in tumor-bearing mice. Therefore, this study suggests that TAT-mediated chitosan/DOX conjugate delivery is effective in slowing tumor growth. Copyright © 2010 UICC. | - |
dc.language | English | - |
dc.title | Cell-penetrating chitosan/doxorubicin/TAT conjugates for efficient cancer therapy | - |
dc.type | Article | - |
dc.relation.issue | 10 | - |
dc.relation.volume | 128 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2470 | - |
dc.relation.lastpage | 2480 | - |
dc.relation.journaltitle | International Journal of Cancer | - |
dc.identifier.doi | 10.1002/ijc.25578 | - |
dc.identifier.wosid | WOS:000288816000023 | - |
dc.identifier.scopusid | 2-s2.0-79953169511 | - |
dc.author.google | Lee J.-Y. | - |
dc.author.google | Choi Y.-S. | - |
dc.author.google | Suh J.-S. | - |
dc.author.google | Kwon Y.-M. | - |
dc.author.google | Yang V.C. | - |
dc.author.google | Lee S.-J. | - |
dc.author.google | Chung C.-P. | - |
dc.author.google | Park Y.-J. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230118105419 | - |