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Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase i inhibitors

Title
Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase i inhibitors
Authors
Khadka D.B.Le Q.M.Yang S.H.Van H.T.M.Le T.N.Cho S.H.Kwon Y.Lee K.-T.Lee E.-S.Cho W.-J.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2011
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 19, no. 6, pp. 1924 - 1929
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Various 5-amino group-substituted indeno[1,2-c]isoquinolines 7a-f were synthesized based on the previous QSAR study as rigid structures of 3-arylisoquinolines. Amino group-substituted compounds, especially 5-piperazinyl indeno[1,2-c]isoquinoline 7f, displayed potent topoisomerase I inhibitory activity as well as cytotoxicities against five different tumor cell lines. A Surflex-Dock docking model of 7f was also studied. © 2011 Elsevier B.V. All rights reserved.
DOI
10.1016/j.bmc.2011.01.064
Appears in Collections:
약학대학 > 약학과 > Journal papers
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