DSpace at EWHA: Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase i inhibitors

Browse

My Repository

View : 559 Download: 0

Full metadata record

DC Field	Value	Language
dc.contributor.author	권영주	*
dc.date.accessioned	2016-08-28T12:08:23Z	-
dc.date.available	2016-08-28T12:08:23Z	-
dc.date.issued	2011	*
dc.identifier.issn	0968-0896	*
dc.identifier.other	OAK-7407	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/221478	-
dc.description.abstract	Various 5-amino group-substituted indeno[1,2-c]isoquinolines 7a-f were synthesized based on the previous QSAR study as rigid structures of 3-arylisoquinolines. Amino group-substituted compounds, especially 5-piperazinyl indeno[1,2-c]isoquinoline 7f, displayed potent topoisomerase I inhibitory activity as well as cytotoxicities against five different tumor cell lines. A Surflex-Dock docking model of 7f was also studied. © 2011 Elsevier B.V. All rights reserved.	*
dc.language	English	*
dc.title	Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase i inhibitors	*
dc.type	Article	*
dc.relation.issue	6	*
dc.relation.volume	19	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	1924	*
dc.relation.lastpage	1929	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry	*
dc.identifier.doi	10.1016/j.bmc.2011.01.064	*
dc.identifier.wosid	WOS:000288196900009	*
dc.identifier.scopusid	2-s2.0-79952442830	*
dc.author.google	Khadka D.B.	*
dc.author.google	Le Q.M.	*
dc.author.google	Yang S.H.	*
dc.author.google	Van H.T.M.	*
dc.author.google	Le T.N.	*
dc.author.google	Cho S.H.	*
dc.author.google	Kwon Y.	*
dc.author.google	Lee K.-T.	*
dc.author.google	Lee E.-S.	*
dc.author.google	Cho W.-J.	*
dc.contributor.scopusid	권영주(12446435600)	*
dc.date.modifydate	20240422124907	*