View : 15 Download: 0

Rapid and reliable measurement for evaluating directly the reactivity of N -acetylcysteine with glucose degradation products in peritoneal dialysis fluids

Title
Rapid and reliable measurement for evaluating directly the reactivity of N -acetylcysteine with glucose degradation products in peritoneal dialysis fluids
Authors
Lee E.Seo E.-Y.Kwon Y.Ha H.
Ewha Authors
하헌주권영주
SCOPUS Author ID
하헌주scopus; 권영주scopus
Issue Date
2011
Journal Title
Analytical Chemistry
ISSN
0003-2700JCR Link
Citation
vol. 83, no. 5, pp. 1518 - 1522
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In this report, we analyzed the reactivity of N-acetyl-l-cysteine (NAC) with glucose degradation products (GDPs) and the stability of NAC in peritoneal dialysis fluids (PDFs) using RP-HPLC and LC-ESI-TOF-MS. NAC reduced the amount of 3,4-dideoxyglucosone-3-ene (3,4-DGE), most toxic among GDPs in PDFs by forming NAC-DGE conjugate under nonenzymatic conditions. NAC was retained as a reduced monomer form in the high-glucose compartment of dual-chambered neutral-pH type PDF, whereas it easily formed a homodimer in an incubation-time-dependent manner in other solutions. The present investigation suggests that NAC can be employed as an adjuvant added into the high-glucose compartment of neutral-pH type PDFs (N-PDF) to reduce GDP-mediated peritoneal membrane failure in patients on long-term peritoneal dialysis (PD) treatment. © 2011 American Chemical Society.
DOI
10.1021/ac200046y
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE