Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하헌주 | * |
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-28T12:08:19Z | - |
dc.date.available | 2016-08-28T12:08:19Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0003-2700 | * |
dc.identifier.other | OAK-7357 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221432 | - |
dc.description.abstract | In this report, we analyzed the reactivity of N-acetyl-l-cysteine (NAC) with glucose degradation products (GDPs) and the stability of NAC in peritoneal dialysis fluids (PDFs) using RP-HPLC and LC-ESI-TOF-MS. NAC reduced the amount of 3,4-dideoxyglucosone-3-ene (3,4-DGE), most toxic among GDPs in PDFs by forming NAC-DGE conjugate under nonenzymatic conditions. NAC was retained as a reduced monomer form in the high-glucose compartment of dual-chambered neutral-pH type PDF, whereas it easily formed a homodimer in an incubation-time-dependent manner in other solutions. The present investigation suggests that NAC can be employed as an adjuvant added into the high-glucose compartment of neutral-pH type PDFs (N-PDF) to reduce GDP-mediated peritoneal membrane failure in patients on long-term peritoneal dialysis (PD) treatment. © 2011 American Chemical Society. | * |
dc.language | English | * |
dc.title | Rapid and reliable measurement for evaluating directly the reactivity of N -acetylcysteine with glucose degradation products in peritoneal dialysis fluids | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 83 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1518 | * |
dc.relation.lastpage | 1522 | * |
dc.relation.journaltitle | Analytical Chemistry | * |
dc.identifier.doi | 10.1021/ac200046y | * |
dc.identifier.wosid | WOS:000287685800007 | * |
dc.identifier.scopusid | 2-s2.0-79952142736 | * |
dc.author.google | Lee E. | * |
dc.author.google | Seo E.-Y. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Ha H. | * |
dc.contributor.scopusid | 하헌주(7202277106) | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422113229 | * |