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Simultaneous GC-MS analysis of melatonin and its precursors as ethoxycarbonyl/pentafluoropropionyl derivatives in rat urine

Title
Simultaneous GC-MS analysis of melatonin and its precursors as ethoxycarbonyl/pentafluoropropionyl derivatives in rat urine
Authors
Paik M.J.Nguyen D.T.Kim Y.J.Shin J.Y.Shim W.Cho E.Y.Yoon J.H.Kim K.R.Lee Y.S.Kim N.Park S.W.Lee G.Ahn Y.H.
Ewha Authors
이윤실
SCOPUS Author ID
이윤실scopus
Issue Date
2010
Journal Title
Chromatographia
ISSN
0009-5893JCR Link
Citation
vol. 72, no. 41590, pp. 1213 - 1217
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Melatonin is synthesized from acetylserotonin, which is a deacetylated product of serotoinin. Simultaneous analysis of melatonin and its precursors in rat urine was performed using their (N,O)-ethoxycarbonyl/N-pentafluoropropionyl (EOC/PFP) derivatives by gas chromatography-mass spectrometry (GC-MS). The mass spectral data of acetylserotonin as mono-O-EOC/mono-N-PFP and serotonin as di-(N,O)-EOC/di-N-PFP derivatives were newly established. This method exhibited good linearity (r ≥ 0.996), repeatability (% relative standard deviation = 6.9-9.4), accuracy (% relative error = -8.9 to 8.6) with detection limits of 0.005 to 0.03 ng mL-1. This method was developed for the simultaneous measurement of melatonin and its precursors in rat urine. © 2010 Vieweg+Teubner Verlag

Springer Fachmedien Wiesbaden GmbH.
DOI
10.1365/s10337-010-1771-y
Appears in Collections:
약학대학 > 약학과 > Journal papers
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