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Anticancer drug encapsulated in inorganic lattice can overcome drug resistance
- Anticancer drug encapsulated in inorganic lattice can overcome drug resistance
- Choi S.-J.; Choi G.E.; Oh J.-M.; Oh Y.-J.; Park M.-C.; Choy J.-H.
- Ewha Authors
- 최진호; 박명철
- SCOPUS Author ID
- Issue Date
- Journal Title
- Journal of Materials Chemistry
- Journal of Materials Chemistry vol. 20, no. 42, pp. 9463 - 9469
- Document Type
- A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries. © 2010 The Royal Society of Chemistry.
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