View : 18 Download: 0

Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

Title
Anticancer drug encapsulated in inorganic lattice can overcome drug resistance
Authors
Choi S.-J.Choi G.E.Oh J.-M.Oh Y.-J.Park M.-C.Choy J.-H.
Ewha Authors
최진호박명철
SCOPUS Author ID
최진호scopus
Issue Date
2010
Journal Title
Journal of Materials Chemistry
ISSN
0959-9428JCR Link
Citation
vol. 20, no. 42, pp. 9463 - 9469
Indexed
SCOPUS WOS scopus
Abstract
A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries. © 2010 The Royal Society of Chemistry.
DOI
10.1039/b925831k
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE