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dc.contributor.author최진호-
dc.contributor.author박명철-
dc.date.accessioned2016-08-28T12:08:48Z-
dc.date.available2016-08-28T12:08:48Z-
dc.date.issued2010-
dc.identifier.issn0959-9428-
dc.identifier.otherOAK-6995-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/221119-
dc.description.abstractA methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries. © 2010 The Royal Society of Chemistry.-
dc.languageEnglish-
dc.titleAnticancer drug encapsulated in inorganic lattice can overcome drug resistance-
dc.typeArticle-
dc.relation.issue42-
dc.relation.volume20-
dc.relation.indexSCOPUS-
dc.relation.startpage9463-
dc.relation.lastpage9469-
dc.relation.journaltitleJournal of Materials Chemistry-
dc.identifier.doi10.1039/b925831k-
dc.identifier.wosidWOS:000283264500023-
dc.identifier.scopusid2-s2.0-78049255413-
dc.author.googleChoi S.-J.-
dc.author.googleChoi G.E.-
dc.author.googleOh J.-M.-
dc.author.googleOh Y.-J.-
dc.author.googlePark M.-C.-
dc.author.googleChoy J.-H.-
dc.contributor.scopusid최진호(8044393000)-
dc.date.modifydate20190301081000-
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