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Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo

Title
Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo
Authors
Lee J.Kim N.H.Nam J.W.Lee Y.M.Jang D.S.Kim Y.S.Nam S.H.Seo E.-K.Yang M.S.Kim J.S.
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2010
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 33, no. 9, pp. 1317 - 1323
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Five compounds previously known structures, scopoletin (1), northalifoline (2), stigmast-4-en-3-one (3), tiliroside (4), and oplopanone (5) were obtained from the flower buds of Magnolia fargesii using chromatographic separation methods. The structures of 1-5 were identified by the interpretation of their spectroscopic data including 1D- and 2D-NMR as well as by comparison with reported values. Three compounds 1-3 were found from M. fargesii for the first time in this study. All the isolates (1-5) were subjected to in vitro bioassays to evaluate the inhibitory activity on advanced glycation end products formation and rat lens aldose reductase (RLAR). Compound 1 showed a remarkable inhibitory activity on advanced glycation end products formation with IC50 value of 2.93 μM (aminoguanidine: 961 μM), and showed a significant RLAR inhibitory activity with IC50 value of 22.5 μM (3.3-tetramethyleneglutaric acid: 28.7 μM). Compound 4 exhibited potent inhibitory activity against RLAR (IC50 = 14.9 μM). In the further experiment ex vivo, cataractogenesis of rat lenses induced with xylose was significantly inhibited by compound 1 treatment. © 2010 The Pharmaceutical Society of Korea and Springer Netherlands.
DOI
10.1007/s12272-010-0904-z
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약학대학 > 약학과 > Journal papers
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