Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-28T12:08:45Z | - |
dc.date.available | 2016-08-28T12:08:45Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-6946 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221080 | - |
dc.description.abstract | Five compounds previously known structures, scopoletin (1), northalifoline (2), stigmast-4-en-3-one (3), tiliroside (4), and oplopanone (5) were obtained from the flower buds of Magnolia fargesii using chromatographic separation methods. The structures of 1-5 were identified by the interpretation of their spectroscopic data including 1D- and 2D-NMR as well as by comparison with reported values. Three compounds 1-3 were found from M. fargesii for the first time in this study. All the isolates (1-5) were subjected to in vitro bioassays to evaluate the inhibitory activity on advanced glycation end products formation and rat lens aldose reductase (RLAR). Compound 1 showed a remarkable inhibitory activity on advanced glycation end products formation with IC50 value of 2.93 μM (aminoguanidine: 961 μM), and showed a significant RLAR inhibitory activity with IC50 value of 22.5 μM (3.3-tetramethyleneglutaric acid: 28.7 μM). Compound 4 exhibited potent inhibitory activity against RLAR (IC50 = 14.9 μM). In the further experiment ex vivo, cataractogenesis of rat lenses induced with xylose was significantly inhibited by compound 1 treatment. © 2010 The Pharmaceutical Society of Korea and Springer Netherlands. | * |
dc.language | English | * |
dc.title | Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 33 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1317 | * |
dc.relation.lastpage | 1323 | * |
dc.relation.journaltitle | Archives of Pharmacal Research | * |
dc.identifier.doi | 10.1007/s12272-010-0904-z | * |
dc.identifier.wosid | WOS:000282476400005 | * |
dc.identifier.scopusid | 2-s2.0-78449255929 | * |
dc.author.google | Lee J. | * |
dc.author.google | Kim N.H. | * |
dc.author.google | Nam J.W. | * |
dc.author.google | Lee Y.M. | * |
dc.author.google | Jang D.S. | * |
dc.author.google | Kim Y.S. | * |
dc.author.google | Nam S.H. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Yang M.S. | * |
dc.author.google | Kim J.S. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |