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Oligopeptide delivery carrier for osteoclast precursors

Title
Oligopeptide delivery carrier for osteoclast precursors
Authors
Chi B.Park S.J.Park M.H.Lee S.Y.Jeong B.
Ewha Authors
이수영정병문
SCOPUS Author ID
이수영scopus; 정병문scopus
Issue Date
2010
Journal Title
Bioconjugate Chemistry
ISSN
1043-1802JCR Link
Citation
vol. 21, no. 8, pp. 1473 - 1478
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Dendritic amine and guanidinium group-modified nanoparticles were investigated for the delivery of model peptide drug into primary osteoclast precursor cells (bone marrow macrophages; BMMs). The model peptide drug was encapsulated into the nanoparticle by dropping the drug/carrier dissolved in dimethylsulfoxide/methylene chloride cosolvent into water containing poly(vinyl alcohol) as a stabilizer. Flow cytometry and spectrofluorimetry analysis indicated that the model drug itself was not taken up by the BMMs; however, nanoparticle systems underwent significant cellular uptake. In particular, guanidinium group-modified nanoparticles were taken up more efficiently than amine group-modified ones. Cell viability studies showed that both amine and guanidinium group-modified nanoparticles exhibited no significant cytotoxicity up to 100 μg/mL against the cells. © 2010 American Chemical Society.
DOI
10.1021/bc100066k
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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