Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2016-08-28T12:08:35Z | - |
dc.date.available | 2016-08-28T12:08:35Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 1043-1802 | * |
dc.identifier.other | OAK-6804 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220979 | - |
dc.description.abstract | Dendritic amine and guanidinium group-modified nanoparticles were investigated for the delivery of model peptide drug into primary osteoclast precursor cells (bone marrow macrophages; BMMs). The model peptide drug was encapsulated into the nanoparticle by dropping the drug/carrier dissolved in dimethylsulfoxide/methylene chloride cosolvent into water containing poly(vinyl alcohol) as a stabilizer. Flow cytometry and spectrofluorimetry analysis indicated that the model drug itself was not taken up by the BMMs; however, nanoparticle systems underwent significant cellular uptake. In particular, guanidinium group-modified nanoparticles were taken up more efficiently than amine group-modified ones. Cell viability studies showed that both amine and guanidinium group-modified nanoparticles exhibited no significant cytotoxicity up to 100 μg/mL against the cells. © 2010 American Chemical Society. | * |
dc.language | English | * |
dc.title | Oligopeptide delivery carrier for osteoclast precursors | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 21 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1473 | * |
dc.relation.lastpage | 1478 | * |
dc.relation.journaltitle | Bioconjugate Chemistry | * |
dc.identifier.doi | 10.1021/bc100066k | * |
dc.identifier.wosid | WOS:000280918900012 | * |
dc.identifier.scopusid | 2-s2.0-77955813537 | * |
dc.author.google | Chi B. | * |
dc.author.google | Park S.J. | * |
dc.author.google | Park M.H. | * |
dc.author.google | Lee S.Y. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240415140424 | * |