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Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity

Title
Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity
Authors
Kam Y.L.Rhee H.-K.Rhim H.Back S.K.Na H.S.Choo H.-Y.P.
Ewha Authors
박혜영
SCOPUS Author ID
박혜영scopus
Issue Date
2010
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 18, no. 16, pp. 5938 - 5944
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain. © 2010 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmc.2010.06.082
Appears in Collections:
약학대학 > 약학과 > Journal papers
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