DSpace at EWHA: Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity

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DC Field	Value	Language
dc.contributor.author	박혜영	-
dc.date.accessioned	2016-08-28T12:08:33Z	-
dc.date.available	2016-08-28T12:08:33Z	-
dc.date.issued	2010	-
dc.identifier.issn	0968-0896	-
dc.identifier.other	OAK-6788	-
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/220965	-
dc.description.abstract	Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain. © 2010 Elsevier Ltd. All rights reserved.	-
dc.language	English	-
dc.title	Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity	-
dc.type	Article	-
dc.relation.issue	16	-
dc.relation.volume	18	-
dc.relation.index	SCI	-
dc.relation.index	SCIE	-
dc.relation.index	SCOPUS	-
dc.relation.startpage	5938	-
dc.relation.lastpage	5944	-
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry	-
dc.identifier.doi	10.1016/j.bmc.2010.06.082	-
dc.identifier.wosid	WOS:000280664100017	-
dc.identifier.scopusid	2-s2.0-77955471833	-
dc.author.google	Kam Y.L.	-
dc.author.google	Rhee H.-K.	-
dc.author.google	Rhim H.	-
dc.author.google	Back S.K.	-
dc.author.google	Na H.S.	-
dc.author.google	Choo H.-Y.P.	-
dc.contributor.scopusid	박혜영(34972649500;57200273796)	-
dc.date.modifydate	20230411110509	-