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Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers

Title
Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers
Authors
Gu S.J.Lee J.K.Pae A.N.Chung H.J.Rhim H.Han S.Y.Min S.-J.Cho Y.S.
Ewha Authors
한소엽
SCOPUS Author ID
한소엽scopus
Issue Date
2010
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 20, no. 9, pp. 2705 - 2708
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We have synthesized and biologically evaluated 1,4-diazepane derivatives as T-type calcium channel blockers. In this study, we discovered compound 4s, a potential T-type calcium channel blocker with good selectivity over hERG and N-type calcium channels. In addition, it exhibited favorable pharmacokinetic characteristics for further investigation of T-type calcium channel related diseases. © 2010 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2010.03.084
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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