DSpace at EWHA: Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers

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DC Field	Value	Language
dc.contributor.author	한소엽	-
dc.date.accessioned	2016-08-28T12:08:06Z	-
dc.date.available	2016-08-28T12:08:06Z	-
dc.date.issued	2010	-
dc.identifier.issn	0960-894X	-
dc.identifier.other	OAK-6477	-
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/220706	-
dc.description.abstract	We have synthesized and biologically evaluated 1,4-diazepane derivatives as T-type calcium channel blockers. In this study, we discovered compound 4s, a potential T-type calcium channel blocker with good selectivity over hERG and N-type calcium channels. In addition, it exhibited favorable pharmacokinetic characteristics for further investigation of T-type calcium channel related diseases. © 2010 Elsevier Ltd. All rights reserved.	-
dc.language	English	-
dc.title	Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers	-
dc.type	Article	-
dc.relation.issue	9	-
dc.relation.volume	20	-
dc.relation.index	SCI	-
dc.relation.index	SCIE	-
dc.relation.index	SCOPUS	-
dc.relation.startpage	2705	-
dc.relation.lastpage	2708	-
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	-
dc.identifier.doi	10.1016/j.bmcl.2010.03.084	-
dc.identifier.wosid	WOS:000276816600001	-
dc.identifier.scopusid	2-s2.0-77950943791	-
dc.author.google	Gu S.J.	-
dc.author.google	Lee J.K.	-
dc.author.google	Pae A.N.	-
dc.author.google	Chung H.J.	-
dc.author.google	Rhim H.	-
dc.author.google	Han S.Y.	-
dc.author.google	Min S.-J.	-
dc.author.google	Cho Y.S.	-
dc.contributor.scopusid	한소엽(7405944194)	-
dc.date.modifydate	20200928112844	-