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SNP276G >t polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea

Title
SNP276G >t polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea
Authors
Hwang J.-Y.Park J.E.Choi Y.J.Huh K.B.Kim W.Y.
Ewha Authors
김화영
SCOPUS Author ID
김화영scopus
Issue Date
2010
Journal Title
European Journal of Clinical Nutrition
ISSN
0954-3007JCR Link
Citation
vol. 64, no. 1, pp. 105 - 107
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Few studies have examined an association between SNP276 and the risk of metabolic syndrome (MetS), which accelerates the development of diabetic complications, in patients with type II diabetes mellitus (T2DM). This study examined whether the SNP276G>T polymorphism is associated with risk of MetS in 673 Korean patients with T2DM from an ongoing prospective study. Multiple logistic regression analysis revealed that the OR for MetS was greater in patients with the TT genotype than in those with the GG genotype (OR2.071; 95% CI1.088-3.943) after adjustment of the putative risk factors for MetS. After examining the relationship between serum adiponectin and MetS risk for each genotype, only in patients with the GT genotype, serum adiponectin was negatively associated with the risk of MetS (OR0.287; 95% CI0.193-0.427). The SNP276G>T polymorphism may have an independent role in the determination of MetS in Korean patients with T2DM. © 2010 Macmillan Publishers Limited All rights reserved.
DOI
10.1038/ejcn.2009.94
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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