DSpace at EWHA: 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study

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2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study

Title: 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study

Authors: Basnet A.; Thapa P.; Karki R.; Choi H.; Choi J.H.; Yun M.; Jeong B.-S.; Jahng Y.; Na Y.; Cho W.-J.; Kwon Y.; Lee C.-S.; Lee E.-S.

Citation: Bioorganic and Medicinal Chemistry Letters vol. 20, no. 1, pp. 42 - 47

Abstract: For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed. © 2009 Elsevier Ltd. All rights reserved.