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Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells

Title
Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells
Authors
Yu H.-N.Noh E.-M.Lee Y.-R.Roh S.-G.Song E.-K.Han M.-K.Lee Y.-C.Shim I.K.Lee S.J.Jung S.H.Kim J.-S.Youn H.J.
Ewha Authors
이승진심인경
SCOPUS Author ID
이승진scopus
Issue Date
2008
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 377, no. 1, pp. 242 - 247
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been identified as a potential source of therapy for human cancers. However, PPARγ ligands have a limitation for breast cancer therapy, since estrogen receptor α (ERα) negatively interferes with PPARγ signaling in breast cancer cells. Here we show that ERα inhihits PPARγ transactivity and ERα-mediated inhibition of PPARγ transactivity is blocked by tamoxifen, an estrogen receptor blocker. The activation of ERα with 17-β-estradiol blocked PPRE transactivity induced by troglitazone, a PPARγ ligand, indicating the resistance of ERα-positive breast cancer cells to troglitazone. Indeed, troglitazone inhibited the growth of ERα-negative MDA-MB-231 cells more than that of ERα-positive MCF-7 cells. Combination of troglitazone with tamoxifen led to a marked increase in growth inhibition of ERα-positive MCF-7 cells compared to either agent alone. Our data indicates that troglitazone enhances the growth inhibitory activity of tamoxifen in ERα-positive MCF-7 cells. © 2008 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbrc.2008.09.111
Appears in Collections:
약학대학 > 약학과 > Journal papers
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