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dc.contributor.author이승진-
dc.contributor.author심인경-
dc.date.accessioned2016-08-28T12:08:06Z-
dc.date.available2016-08-28T12:08:06Z-
dc.date.issued2008-
dc.identifier.issn0006-291X-
dc.identifier.otherOAK-5188-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/220090-
dc.description.abstractPeroxisome proliferator-activated receptor γ (PPARγ) ligands have been identified as a potential source of therapy for human cancers. However, PPARγ ligands have a limitation for breast cancer therapy, since estrogen receptor α (ERα) negatively interferes with PPARγ signaling in breast cancer cells. Here we show that ERα inhihits PPARγ transactivity and ERα-mediated inhibition of PPARγ transactivity is blocked by tamoxifen, an estrogen receptor blocker. The activation of ERα with 17-β-estradiol blocked PPRE transactivity induced by troglitazone, a PPARγ ligand, indicating the resistance of ERα-positive breast cancer cells to troglitazone. Indeed, troglitazone inhibited the growth of ERα-negative MDA-MB-231 cells more than that of ERα-positive MCF-7 cells. Combination of troglitazone with tamoxifen led to a marked increase in growth inhibition of ERα-positive MCF-7 cells compared to either agent alone. Our data indicates that troglitazone enhances the growth inhibitory activity of tamoxifen in ERα-positive MCF-7 cells. © 2008 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.titleTroglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume377-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage242-
dc.relation.lastpage247-
dc.relation.journaltitleBiochemical and Biophysical Research Communications-
dc.identifier.doi10.1016/j.bbrc.2008.09.111-
dc.identifier.wosidWOS:000260738500047-
dc.identifier.scopusid2-s2.0-54449088704-
dc.author.googleYu H.-N.-
dc.author.googleNoh E.-M.-
dc.author.googleLee Y.-R.-
dc.author.googleRoh S.-G.-
dc.author.googleSong E.-K.-
dc.author.googleHan M.-K.-
dc.author.googleLee Y.-C.-
dc.author.googleShim I.K.-
dc.author.googleLee S.J.-
dc.author.googleJung S.H.-
dc.author.googleKim J.-S.-
dc.author.googleYoun H.J.-
dc.contributor.scopusid이승진(12545448000)-
dc.date.modifydate20200911081002-
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약학대학 > 약학과 > Journal papers
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