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Identification of a new naphthalene and its derivatives from the bulb of Eleutherine americana with inhibitory activity on lipopolysaccharide-induced nitric oxide production

Title
Identification of a new naphthalene and its derivatives from the bulb of Eleutherine americana with inhibitory activity on lipopolysaccharide-induced nitric oxide production
Authors
Han A.-R.Min H.-Y.Nam J.-W.Lee N.-Y.Wiryawan A.Suprapto W.Lee S.K.Lee K.R.Seo E.-K.
Ewha Authors
이상국서은경한아름
SCOPUS Author ID
서은경scopus; 한아름scopusscopus
Issue Date
2008
Journal Title
Chemical and Pharmaceutical Bulletin
ISSN
0009-2363JCR Link
Citation
vol. 56, no. 9, pp. 1314 - 1316
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new naphthoquinone, (-)-3-[2-(acetyloxy)propyl]-2-hydroxy-8-methoxy-1,4- naphthoquinone (1) was isolated from the bulb of Eleutherine americana Merr. et Heyne (Iridaceae) together with two known compounds, eleutherinol (6) and 1,5-dihydroxy-3-methylanthraquinone (7) which were found in this species for the first time. The other known compounds, (-)-isoeleutherin (2), (+)-eleutherin (3), (-)-hongconin (4), and (+)-dihydroeleutherinol (5) which were reported previously from this species, were also isolated in the present study. Compounds 2-6 exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 lipopolysaccharide-activated mouse macrophage cells with IC50 values of 7.7, 11.4, 19.8, 21.7, and 34.4 μm, respectively, whereas the other two compounds, 1 and 7, were inactive. The structure of compound 1 was elucidated by spectroscopic data analysis including 1D and 2D NMR experiments. © 2008 Pharmaceutical Society of Japan.
DOI
10.1248/cpb.56.1314
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약학대학 > 약학과 > Journal papers
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