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Topoisomerase-II-Inhibitory principles from the stems of Spatholobus suberectus

Title
Topoisomerase-II-Inhibitory principles from the stems of Spatholobus suberectus
Authors
Han A.-R.Park H.J.Chen D.Jang D.S.Kim H.-J.Lee S.K.Seo E.-K.
Ewha Authors
김화정이상국서은경한아름
SCOPUS Author ID
김화정scopus; 서은경scopus; 한아름scopusscopus
Issue Date
2007
Journal Title
Chemistry and Biodiversity
ISSN
1612-1872JCR Link
Citation
vol. 4, no. 7, pp. 1487 - 1491
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (=(+)-catechin-(4→8)-(-)-epicatechin) (1) and (+)-catechin-(4→8)-(+)-catechin(4→8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC50 values of 22.5 ± 2.3 and 21.9 ±2.2 nM, resp. © 2007 Verlag Helvetica Chimica Acta AG, Zürich.
DOI
10.1002/cbdv.200790127
Appears in Collections:
약학대학 > 약학과 > Journal papers
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