Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김양하 | * |
dc.date.accessioned | 2016-08-28T12:08:36Z | - |
dc.date.available | 2016-08-28T12:08:36Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 1096-620X | * |
dc.identifier.other | OAK-3767 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219802 | - |
dc.description.abstract | We investigated the lipolytic effects of L-carnitine in 3T3-L1 adipocytes. L-carnitine at 10-100 nM suppressed lipid accumulation. The release of glycerol and free fatty acid into the medium was significantly increased by 1.5- and 1.7-fold, respectively, by the addition of 100 nM L-carnitine compared with the control (P < .05). The mRNA levels of hormone-sensitive lipase, carnitine palmitoyltransferase I-a, and acyl-coenzyme A oxidase, all of which participate in lipid catabolism, were increased in the presence of 100 nM L-carnitine by 2.8-, 2.2-, and 1.6-fold, respectively (P < .05). However, the expression of peroxisome proliferator-activated receptor-γ and adipose-specific fatty acid-binding protein, which are involved in adipogenesis, were down-regulated by L-carnitine in 3T3-L1 adipocytes (P < .05). These results suggest an anti-obesity action of L-carnitine. L-carnitine may modulate lipid metabolism by stimulation of lipolysis and β-oxidation accompanied by corresponding changes in gene expression and suppression of adipogenic gene expression. © Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition. | * |
dc.language | English | * |
dc.title | L-carnitine stimulates lipolysis via induction of the lipolytic gene expression and suppression of the adipogenic gene expression in 3T3-L1 adipocytes | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 468 | * |
dc.relation.lastpage | 473 | * |
dc.relation.journaltitle | Journal of Medicinal Food | * |
dc.identifier.wosid | WOS:000243393400004 | * |
dc.identifier.scopusid | 2-s2.0-33846203944 | * |
dc.author.google | Lee M.-S. | * |
dc.author.google | Lee H.-J. | * |
dc.author.google | Lee H.-S. | * |
dc.author.google | Kim Y. | * |
dc.contributor.scopusid | 김양하(8524160300) | * |
dc.date.modifydate | 20240123090847 | * |