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Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6
- Title
- Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6
- Authors
- Yoon T.; Kim M.; Lee K.
- Ewha Authors
- 이경림; 윤태숙
- SCOPUS Author ID
- 이경림; 윤태숙
- Issue Date
- 2006
- Journal Title
- FEBS Letters
- ISSN
- 0014-5793
- Citation
- FEBS Letters vol. 580, no. 14, pp. 3558 - 3564
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Translationally controlled tumor protein (TCTP) has both extra- and intracellular functions. Our group recently reported that TCTP interacts with Na,K-ATPase and suppresses its activity. Our studies led to the identification of sorting nexin 6 (SNX6) which binds with TCTP as a potential negative regulator of TCTP. SNX6 does not interact directly with any cytoplasmic domains of Na,K-ATPase. However, when overexpressed, it restores the Na,K-ATPase activity suppressed by TCTP. This was confirmed by measurements of purified plasma membrane Na,K-ATPase activity after incubation with recombinant TCTP and SNX6. SNX6 alone has no effect on Na,K-ATPase activity, but activates Na,K-ATPase via inhibition of TCTP. Inhibition of endogenous TCTP by the overexpression of SNX6 or knockdown of TCTP expression by siTCTP increased Na,K-ATPase activity above the basal level. The interaction between SNX6 and TCTP thus appears to regulate Na,K-ATPase activity. © 2006 Federation of European Biochemical Societies.
- DOI
- 10.1016/j.febslet.2006.05.042
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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