Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이경림 | * |
dc.contributor.author | 윤태숙 | * |
dc.date.accessioned | 2016-08-28T11:08:05Z | - |
dc.date.available | 2016-08-28T11:08:05Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0014-5793 | * |
dc.identifier.other | OAK-3385 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219712 | - |
dc.description.abstract | Translationally controlled tumor protein (TCTP) has both extra- and intracellular functions. Our group recently reported that TCTP interacts with Na,K-ATPase and suppresses its activity. Our studies led to the identification of sorting nexin 6 (SNX6) which binds with TCTP as a potential negative regulator of TCTP. SNX6 does not interact directly with any cytoplasmic domains of Na,K-ATPase. However, when overexpressed, it restores the Na,K-ATPase activity suppressed by TCTP. This was confirmed by measurements of purified plasma membrane Na,K-ATPase activity after incubation with recombinant TCTP and SNX6. SNX6 alone has no effect on Na,K-ATPase activity, but activates Na,K-ATPase via inhibition of TCTP. Inhibition of endogenous TCTP by the overexpression of SNX6 or knockdown of TCTP expression by siTCTP increased Na,K-ATPase activity above the basal level. The interaction between SNX6 and TCTP thus appears to regulate Na,K-ATPase activity. © 2006 Federation of European Biochemical Societies. | * |
dc.language | English | * |
dc.title | Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6 | * |
dc.type | Article | * |
dc.relation.issue | 14 | * |
dc.relation.volume | 580 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3558 | * |
dc.relation.lastpage | 3564 | * |
dc.relation.journaltitle | FEBS Letters | * |
dc.identifier.doi | 10.1016/j.febslet.2006.05.042 | * |
dc.identifier.wosid | WOS:000238320100036 | * |
dc.identifier.scopusid | 2-s2.0-33646927288 | * |
dc.author.google | Yoon T. | * |
dc.author.google | Kim M. | * |
dc.author.google | Lee K. | * |
dc.contributor.scopusid | 이경림(7501517435) | * |
dc.contributor.scopusid | 윤태숙(7201604364) | * |
dc.date.modifydate | 20240501081003 | * |