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Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6

Title
Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6
Authors
Yoon T.Kim M.Lee K.
Ewha Authors
이경림윤태숙
SCOPUS Author ID
이경림scopus
Issue Date
2006
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 580, no. 14, pp. 3558 - 3564
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Translationally controlled tumor protein (TCTP) has both extra- and intracellular functions. Our group recently reported that TCTP interacts with Na,K-ATPase and suppresses its activity. Our studies led to the identification of sorting nexin 6 (SNX6) which binds with TCTP as a potential negative regulator of TCTP. SNX6 does not interact directly with any cytoplasmic domains of Na,K-ATPase. However, when overexpressed, it restores the Na,K-ATPase activity suppressed by TCTP. This was confirmed by measurements of purified plasma membrane Na,K-ATPase activity after incubation with recombinant TCTP and SNX6. SNX6 alone has no effect on Na,K-ATPase activity, but activates Na,K-ATPase via inhibition of TCTP. Inhibition of endogenous TCTP by the overexpression of SNX6 or knockdown of TCTP expression by siTCTP increased Na,K-ATPase activity above the basal level. The interaction between SNX6 and TCTP thus appears to regulate Na,K-ATPase activity. © 2006 Federation of European Biochemical Societies.
DOI
10.1016/j.febslet.2006.05.042
Appears in Collections:
약학대학 > 약학과 > Journal papers
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