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Cyclooxygenase-2 inhibitory phenylbutenoids from the rhizomes of Zingiber cassumunar
- Title
- Cyclooxygenase-2 inhibitory phenylbutenoids from the rhizomes of Zingiber cassumunar
- Authors
- Han A.-R.; Kim M.-S.; Jeong Y.H.; Lee S.K.; Seo E.-K.
- Ewha Authors
- 이상국; 서은경; 한아름
- SCOPUS Author ID
- 이상국; 서은경; 한아름
- Issue Date
- 2005
- Journal Title
- Chemical and Pharmaceutical Bulletin
- ISSN
- 0009-2363
- Citation
- Chemical and Pharmaceutical Bulletin vol. 53, no. 11, pp. 1466 - 1468
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Phenylbutenoids 1-6 isolated previously from the CHCl3 extracts of the rhizomes of Zingiber cassumunar, were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity along with a new isolate, 7 from the n-BuOH extracts of this plant. The COX-2 inhibitory assay was performed by measuring prostaglandin E2 production in lipopolysaccharide- stimulated mouse macrophage RAW 264.7 cells. Two phenylbutenoid dimers, 1 and 2, exhibited considerable activity with IC50 values of 2.71 and 3.64 μM. Two phenylbutenoid monomers, 3 and 4, showed moderate activity (IC 50 14.97, 20.68 μM, respectively). The other three phenylbutenoids, 5-7, were found to be inactive. Compound 7 was elucidated as a new phenylbutenoid glycoside, namely, (E)-4-(3,4-dimethoxyphenyl) but-3-en-1-O-β-D-glucopyranoside by spectral analysis including various 1D- and 2D-NMR experiments. © 2005 Pharmaceutical Society of Japan.
- DOI
- 10.1248/cpb.53.1466
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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