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Cyclooxygenase-2 inhibitory phenylbutenoids from the rhizomes of Zingiber cassumunar

Title
Cyclooxygenase-2 inhibitory phenylbutenoids from the rhizomes of Zingiber cassumunar
Authors
Han A.-R.Kim M.-S.Jeong Y.H.Lee S.K.Seo E.-K.
Ewha Authors
이상국서은경한아름
SCOPUS Author ID
서은경scopus; 한아름scopusscopus
Issue Date
2005
Journal Title
Chemical and Pharmaceutical Bulletin
ISSN
0009-2363JCR Link
Citation
vol. 53, no. 11, pp. 1466 - 1468
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Phenylbutenoids 1-6 isolated previously from the CHCl3 extracts of the rhizomes of Zingiber cassumunar, were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity along with a new isolate, 7 from the n-BuOH extracts of this plant. The COX-2 inhibitory assay was performed by measuring prostaglandin E2 production in lipopolysaccharide- stimulated mouse macrophage RAW 264.7 cells. Two phenylbutenoid dimers, 1 and 2, exhibited considerable activity with IC50 values of 2.71 and 3.64 μM. Two phenylbutenoid monomers, 3 and 4, showed moderate activity (IC 50 14.97, 20.68 μM, respectively). The other three phenylbutenoids, 5-7, were found to be inactive. Compound 7 was elucidated as a new phenylbutenoid glycoside, namely, (E)-4-(3,4-dimethoxyphenyl) but-3-en-1-O-β-D-glucopyranoside by spectral analysis including various 1D- and 2D-NMR experiments. © 2005 Pharmaceutical Society of Japan.
DOI
10.1248/cpb.53.1466
Appears in Collections:
약학대학 > 약학과 > Journal papers
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