Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상국 | * |
dc.contributor.author | 서은경 | * |
dc.contributor.author | 한아름 | * |
dc.date.accessioned | 2016-08-28T11:08:58Z | - |
dc.date.available | 2016-08-28T11:08:58Z | - |
dc.date.issued | 2005 | * |
dc.identifier.issn | 0009-2363 | * |
dc.identifier.other | OAK-3014 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219636 | - |
dc.description.abstract | Phenylbutenoids 1-6 isolated previously from the CHCl3 extracts of the rhizomes of Zingiber cassumunar, were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity along with a new isolate, 7 from the n-BuOH extracts of this plant. The COX-2 inhibitory assay was performed by measuring prostaglandin E2 production in lipopolysaccharide- stimulated mouse macrophage RAW 264.7 cells. Two phenylbutenoid dimers, 1 and 2, exhibited considerable activity with IC50 values of 2.71 and 3.64 μM. Two phenylbutenoid monomers, 3 and 4, showed moderate activity (IC 50 14.97, 20.68 μM, respectively). The other three phenylbutenoids, 5-7, were found to be inactive. Compound 7 was elucidated as a new phenylbutenoid glycoside, namely, (E)-4-(3,4-dimethoxyphenyl) but-3-en-1-O-β-D-glucopyranoside by spectral analysis including various 1D- and 2D-NMR experiments. © 2005 Pharmaceutical Society of Japan. | * |
dc.language | English | * |
dc.title | Cyclooxygenase-2 inhibitory phenylbutenoids from the rhizomes of Zingiber cassumunar | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 53 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1466 | * |
dc.relation.lastpage | 1468 | * |
dc.relation.journaltitle | Chemical and Pharmaceutical Bulletin | * |
dc.identifier.doi | 10.1248/cpb.53.1466 | * |
dc.identifier.wosid | WOS:000233350600018 | * |
dc.identifier.scopusid | 2-s2.0-27744555241 | * |
dc.author.google | Han A.-R. | * |
dc.author.google | Kim M.-S. | * |
dc.author.google | Jeong Y.H. | * |
dc.author.google | Lee S.K. | * |
dc.author.google | Seo E.-K. | * |
dc.contributor.scopusid | 이상국(36067620500) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 한아름(56278315000;34769874800) | * |
dc.date.modifydate | 20240130112016 | * |