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Folic acid supplementation can reduce the endothelial damage in rat brain microvasculature due to hyperhomocysteinemia

Title
Folic acid supplementation can reduce the endothelial damage in rat brain microvasculature due to hyperhomocysteinemia
Authors
Lee H.Kim J.-M.Ho J.K.Lee I.Chang N.
Ewha Authors
장남수이화영
SCOPUS Author ID
장남수scopus; 이화영scopus
Issue Date
2005
Journal Title
Journal of Nutrition
ISSN
0022-3166JCR Link
Citation
vol. 135, no. 3, pp. 544 - 548
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
To evaluate the effects of dietary folic acid supplementation on the cerebral vascular damage induced by hyperhomocysteinemia, rats were fed a diet containing 3.0 g/kg homocystine for 2 wk and then either 3.0 g/kg homocystine or 3.0 g/kg homocystine plus 0.008 g/kg folic acid for 8 wk. Control rats consumed the AIN-93 Maintenance diet throughout the experiment. The cerebral expression of glucose transporter-1 was measured by Western blot analysis and cerebrovascular structural alterations were evaluated by electron microscopy. The homocystine diet significantly increased the plasma levels of homocysteine and TBARS and decreased the cerebral expression of glucose transporter-1 (GLUT-1) with a concomitant increase in the percentage of damaged cerebral vessels. The inclusion of dietary folic acid for 8 wk caused plasma homocysteine levels to be the same as in control rats and it significantly upregulated the cerebral expression of GLUT-1 that was significantly reduced by hyperhomocysteinemia. Folic acid supplementation also significantly decreased the incidence of damaged vessels due to hyperhomocysteinemia. These results and the electron microscopy findings suggested that folic acid supplementation might reduce the detrimental effects on the endothelium caused by experimentally induced hyperhomocysteinemia. © 2005 American Society for Nutritional Sciences.
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신산업융합대학 > 식품영양학과 > Journal papers
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