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Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide- mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia

Title
Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide- mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia
Authors
Kim H.-S.Whang S.-Y.Woo M.-S.Park J.-S.Kim W.-K.Han I.-O.
Ewha Authors
김원기김희선박진선
SCOPUS Author ID
김희선scopus; 박진선scopus
Issue Date
2004
Journal Title
Journal of Neuroimmunology
ISSN
0165-5728JCR Link
Citation
vol. 151, no. 41276, pp. 85 - 93
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In the present study, we demonstrate that sodium butyrate repressed IFN-γ-induced expression of iNOS and TNF-α, but had little effect on LPS-induced expression in BV2 murine microglial cells. Sodium butyrate significantly inhibited NF-κB binding and NF-κB-mediated transcription induced by IFN-γ, suggesting that the anti-inflammatory effect of sodium butyrate is mediated via specific inhibition of the NF-κB pathway. IFN-γ is a major stimulator of innate and adaptive immune response. Thus, the specific down-regulation of IFN-γ-induced microglial activation by sodium butyrate may provide potential therapeutic strategies for a variety of inflammatory diseases in the central nervous system. © 2004 Elsevier B.V. All rights reserved.
DOI
10.1016/j.jneuroim.2004.02.006
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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