Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원기 | * |
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박진선 | * |
dc.date.accessioned | 2016-08-28T11:08:40Z | - |
dc.date.available | 2016-08-28T11:08:40Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 0165-5728 | * |
dc.identifier.other | OAK-2206 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219433 | - |
dc.description.abstract | In the present study, we demonstrate that sodium butyrate repressed IFN-γ-induced expression of iNOS and TNF-α, but had little effect on LPS-induced expression in BV2 murine microglial cells. Sodium butyrate significantly inhibited NF-κB binding and NF-κB-mediated transcription induced by IFN-γ, suggesting that the anti-inflammatory effect of sodium butyrate is mediated via specific inhibition of the NF-κB pathway. IFN-γ is a major stimulator of innate and adaptive immune response. Thus, the specific down-regulation of IFN-γ-induced microglial activation by sodium butyrate may provide potential therapeutic strategies for a variety of inflammatory diseases in the central nervous system. © 2004 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide- mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia | * |
dc.type | Article | * |
dc.relation.issue | 41276 | * |
dc.relation.volume | 151 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 85 | * |
dc.relation.lastpage | 93 | * |
dc.relation.journaltitle | Journal of Neuroimmunology | * |
dc.identifier.doi | 10.1016/j.jneuroim.2004.02.006 | * |
dc.identifier.wosid | WOS:000221895000010 | * |
dc.identifier.scopusid | 2-s2.0-2442549715 | * |
dc.author.google | Kim H.-S. | * |
dc.author.google | Whang S.-Y. | * |
dc.author.google | Woo M.-S. | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Kim W.-K. | * |
dc.author.google | Han I.-O. | * |
dc.contributor.scopusid | 김원기(34770946200) | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박진선(54914743600) | * |
dc.date.modifydate | 20240215165648 | * |