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Syndecans-2 and -4; close cousins, but not identical twins

Title
Syndecans-2 and -4; close cousins, but not identical twins
Authors
Oh E.-S.Couchman J.R.
Ewha Authors
오억수
SCOPUS Author ID
오억수scopus
Issue Date
2004
Journal Title
Molecules and Cells
ISSN
1016-8478JCR Link
Citation
vol. 17, no. 2, pp. 181 - 187
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
The vertebrate syndecans, which make up a four-member family of small type I transmembrane heparan sulfate proteoglycans, constitute evolutionarily conserved family proteins. In particular, sequences in the transmembrane and cytoplasmic domains are a unifying feature within the family. However, the extracellular domain sequences are molecule-specific, implying that different syndecans have evolved to carry out similar, but non-identical, functions. While all four syndecans have been implicated in regulation of the cytoskeleton, their roles are clearly complex. Recent developments indicate that the closely related syndecan-2 and -4 have separable functions, though both bind a number of ligands through their heparan sulfate chains. The specification of these activities is probably core protein related, but is it due to a distinct expression pattern or molecule-specific regulatory mechanisms? Although there is not yet enough data to provide unambiguous answers, here we shall review the known functions and regulatory mechanisms of syndecan-2 and -4. ©KSMCB 2004.
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자연과학대학 > 생명과학전공 > Journal papers
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