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Syndecans-2 and -4; close cousins, but not identical twins
- Syndecans-2 and -4; close cousins, but not identical twins
- Oh E.-S.; Couchman J.R.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Molecules and Cells
- vol. 17, no. 2, pp. 181 - 187
- SCI; SCIE; SCOPUS; KCI
- The vertebrate syndecans, which make up a four-member family of small type I transmembrane heparan sulfate proteoglycans, constitute evolutionarily conserved family proteins. In particular, sequences in the transmembrane and cytoplasmic domains are a unifying feature within the family. However, the extracellular domain sequences are molecule-specific, implying that different syndecans have evolved to carry out similar, but non-identical, functions. While all four syndecans have been implicated in regulation of the cytoskeleton, their roles are clearly complex. Recent developments indicate that the closely related syndecan-2 and -4 have separable functions, though both bind a number of ligands through their heparan sulfate chains. The specification of these activities is probably core protein related, but is it due to a distinct expression pattern or molecule-specific regulatory mechanisms? Although there is not yet enough data to provide unambiguous answers, here we shall review the known functions and regulatory mechanisms of syndecan-2 and -4. ©KSMCB 2004.
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