Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장남수 | * |
dc.contributor.author | 김영주 | * |
dc.date.accessioned | 2016-08-28T11:08:33Z | - |
dc.date.available | 2016-08-28T11:08:33Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 0954-3007 | * |
dc.identifier.other | OAK-1762 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219356 | - |
dc.description.abstract | Objective: The purpose of this study was to investigate the effect of the interaction between the C677T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotypes and serum levels of B vitamins on serum homocysteine levels in pregnant women. Design: A cross-sectional study. Setting: Ewha Womans University Hospital, Seoul, Korea. Subjects: A total of 177 normal pregnant women, 24.6 ± 1.1 weeks of gestation, in a 6-month period during 2001-2002. Interventions: Serum vitamin B2, vitamin B6, and homocysteine analyses were conducted using high-performance liquid chromatography methods. Serum folate and vitamin B12 concentrations were determined using a radioimmunoassay kit. MTHFR gene mutation was investigated by the polymerase chain reaction of a genomic DNA fragment. Results: Serum homocysteine was higher in women with the T/T genotype than those with the C/T or C/C genotype of the MTHFR gene (P<0.05). Serum homocysteine was negatively correlated with serum folate in all MTHFR genotypes (P<0.001), and the correlation between the two serum levels was the strongest in the T/T genotype. Serum homocysteine was higher in the subjects with the T/T MTHFR genotype only when the serum folate was below the median level. Explanatory power of B vitamin status as predictors of serum homocysteine levels was more pronounced in the T/T genotypes (68.5%) compared with the C/T (37.9%) or C/C genotypes (20.6%). Conclusions: Serum homocysteine levels in pregnant women varied significantly with MTHFR genotype and the serum B vitamin status. Higher serum folate, vitamin B2, and vitamin B12 concentrations may lessen the MTHFR genotypic effect on serum homocysteine levels. | * |
dc.language | English | * |
dc.title | Effects of the interaction between the C677T 5, 10-methylenetetrahydrofolate reductase polymorphism and serum B vitamins on homocysteine levels in pregnant women | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 58 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 10 | * |
dc.relation.lastpage | 16 | * |
dc.relation.journaltitle | European Journal of Clinical Nutrition | * |
dc.identifier.doi | 10.1038/sj.ejcn.1601729 | * |
dc.identifier.wosid | WOS:000187286900002 | * |
dc.identifier.scopusid | 2-s2.0-0742324549 | * |
dc.author.google | Kim K.N. | * |
dc.author.google | Kim Y.J. | * |
dc.author.google | Chang N. | * |
dc.contributor.scopusid | 장남수(7202467832;56447965800) | * |
dc.contributor.scopusid | 김영주(55801681000) | * |
dc.date.modifydate | 20240415132200 | * |