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Synthesis and cytotoxicity of new platinum(IV) complexes of mixed carboxylates
- Title
- Synthesis and cytotoxicity of new platinum(IV) complexes of mixed carboxylates
- Authors
- Song R.; Park S.Y.; Kim Y.-S.; Kim Y.; Kim S.-J.; Ahn B.T.; Sohn Y.S.
- Ewha Authors
- 안병태; 김성진; 김영미; 손연수
- SCOPUS Author ID
- 안병태; 김성진; 김영미; 손연수
- Issue Date
- 2003
- Journal Title
- Journal of Inorganic Biochemistry
- ISSN
- 0162-0134
- Citation
- Journal of Inorganic Biochemistry vol. 96, no. 2-3, pp. 339 - 345
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- In order to develop new antitumor platinum(IV) complexes with highly tuned lipophilicity, a series of (diamine)Pt(IV) complexes of the formula [PtIV(dach)L3L′] or [PtIV(dach)L2L″2] (dach=trans-(±)-1,2-diaminocyclohexane; L=acetato, propionato; L′=acetato, propionato, valerato or pivalato; L″=trifluoroacetato) have been synthesized by electrophilic substitution of the tris(carboxylato)hydroxoplatinum(IV) complexes, [PtIV(dach)L3OH] (L=acetato, propionato), with various carboxylic anhydrides such as acetic, trifluoroacetic, pivalic and valeric anhydrides. The present platinum(IV) complexes were fully characterized by means of elemental analyses, 1H NMR, mass and IR spectroscopies. The complexes 8 and 10, satisfying the appropriate range of lipophilicity (logP=0.18-1.54), exhibited high activity (ED50, 5.1 and 1.3 μM, respectively) compared with other complexes, which implies that the lipophilicity is an important factor for the antitumor activity of this series of complexes. © 2003 Elsevier Inc. All rights reserved.
- DOI
- 10.1016/S0162-0134(03)00149-1
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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