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Synthesis and cytotoxicity of new platinum(IV) complexes of mixed carboxylates

Title
Synthesis and cytotoxicity of new platinum(IV) complexes of mixed carboxylates
Authors
Song R.Park S.Y.Kim Y.-S.Kim Y.Kim S.-J.Ahn B.T.Sohn Y.S.
Ewha Authors
안병태김성진김영미손연수
SCOPUS Author ID
안병태scopusscopus; 김성진scopus; 김영미scopus; 손연수scopus
Issue Date
2003
Journal Title
Journal of Inorganic Biochemistry
ISSN
0162-0134JCR Link
Citation
vol. 96, no. 2-3, pp. 339 - 345
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In order to develop new antitumor platinum(IV) complexes with highly tuned lipophilicity, a series of (diamine)Pt(IV) complexes of the formula [PtIV(dach)L3L′] or [PtIV(dach)L2L″2] (dach=trans-(±)-1,2-diaminocyclohexane; L=acetato, propionato; L′=acetato, propionato, valerato or pivalato; L″=trifluoroacetato) have been synthesized by electrophilic substitution of the tris(carboxylato)hydroxoplatinum(IV) complexes, [PtIV(dach)L3OH] (L=acetato, propionato), with various carboxylic anhydrides such as acetic, trifluoroacetic, pivalic and valeric anhydrides. The present platinum(IV) complexes were fully characterized by means of elemental analyses, 1H NMR, mass and IR spectroscopies. The complexes 8 and 10, satisfying the appropriate range of lipophilicity (logP=0.18-1.54), exhibited high activity (ED50, 5.1 and 1.3 μM, respectively) compared with other complexes, which implies that the lipophilicity is an important factor for the antitumor activity of this series of complexes. © 2003 Elsevier Inc. All rights reserved.
DOI
10.1016/S0162-0134(03)00149-1
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자연과학대학 > 화학·나노과학전공 > Journal papers
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