Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안병태 | * |
dc.contributor.author | 김성진 | * |
dc.contributor.author | 김영미 | * |
dc.contributor.author | 손연수 | * |
dc.date.accessioned | 2016-08-28T11:08:25Z | - |
dc.date.available | 2016-08-28T11:08:25Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0162-0134 | * |
dc.identifier.other | OAK-1572 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219261 | - |
dc.description.abstract | In order to develop new antitumor platinum(IV) complexes with highly tuned lipophilicity, a series of (diamine)Pt(IV) complexes of the formula [PtIV(dach)L3L′] or [PtIV(dach)L2L″2] (dach=trans-(±)-1,2-diaminocyclohexane; L=acetato, propionato; L′=acetato, propionato, valerato or pivalato; L″=trifluoroacetato) have been synthesized by electrophilic substitution of the tris(carboxylato)hydroxoplatinum(IV) complexes, [PtIV(dach)L3OH] (L=acetato, propionato), with various carboxylic anhydrides such as acetic, trifluoroacetic, pivalic and valeric anhydrides. The present platinum(IV) complexes were fully characterized by means of elemental analyses, 1H NMR, mass and IR spectroscopies. The complexes 8 and 10, satisfying the appropriate range of lipophilicity (logP=0.18-1.54), exhibited high activity (ED50, 5.1 and 1.3 μM, respectively) compared with other complexes, which implies that the lipophilicity is an important factor for the antitumor activity of this series of complexes. © 2003 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis and cytotoxicity of new platinum(IV) complexes of mixed carboxylates | * |
dc.type | Article | * |
dc.relation.issue | 2-3 | * |
dc.relation.volume | 96 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 339 | * |
dc.relation.lastpage | 345 | * |
dc.relation.journaltitle | Journal of Inorganic Biochemistry | * |
dc.identifier.doi | 10.1016/S0162-0134(03)00149-1 | * |
dc.identifier.wosid | WOS:000184654800007 | * |
dc.identifier.scopusid | 2-s2.0-12444317692 | * |
dc.author.google | Song R. | * |
dc.author.google | Park S.Y. | * |
dc.author.google | Kim Y.-S. | * |
dc.author.google | Kim Y. | * |
dc.author.google | Kim S.-J. | * |
dc.author.google | Ahn B.T. | * |
dc.author.google | Sohn Y.S. | * |
dc.contributor.scopusid | 안병태(55426317800;24315839600) | * |
dc.contributor.scopusid | 김성진(56812714700) | * |
dc.contributor.scopusid | 김영미(57207443602) | * |
dc.contributor.scopusid | 손연수(7201971323) | * |
dc.date.modifydate | 20240301081003 | * |