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Cytotoxic activity and G2/M cell cycle arrest mediated by antofine, a phenanthroindolizidine alkaloid isolated from Cynanchum paniculatum

Title
Cytotoxic activity and G2/M cell cycle arrest mediated by antofine, a phenanthroindolizidine alkaloid isolated from Cynanchum paniculatum
Authors
Lee S.K.Nam K.-A.Heo Y.-H.
Ewha Authors
이상국
Issue Date
2003
Journal Title
Planta Medica
ISSN
0032-0943JCR Link
Citation
vol. 69, no. 1, pp. 21 - 25
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Starting with an extract derived from the root of Cynanchum paniculatum Kitagawa (Asclepiadaceae) that was active in the process of inhibiting the growth of human cancer cells in culture, a phenanthroindolizidine alkaloid antofine was isolated and identified as an active principle (IC50 = 7.0 ± 0.2 ng/ml for A549, human lung cancer cells; IC50 = 8.6 ± 0.3 ng/ml for Co12, human colon cancer cells). Prompted by the high potency of cancer cell growth inhibition, additional action mechanism studies were performed with antofine. Utilizing cultured Co12 cells as a model, antofine induced arrest in the G2/M phase of the cell cycle after 48 h of incubation. With wash-out experiment, colony formation was also inhibited in a dose-dependent manner. These data suggest the potential of antofine to serve as a cancer chemotherapeutic agent by virtue of arresting the cell cycle.
DOI
10.1055/s-2003-37021
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약학대학 > 약학과 > Journal papers
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