Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-28T11:08:14Z | - |
dc.date.available | 2016-08-28T11:08:14Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.other | OAK-1335 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219150 | - |
dc.description.abstract | Starting with an extract derived from the root of Cynanchum paniculatum Kitagawa (Asclepiadaceae) that was active in the process of inhibiting the growth of human cancer cells in culture, a phenanthroindolizidine alkaloid antofine was isolated and identified as an active principle (IC50 = 7.0 ± 0.2 ng/ml for A549, human lung cancer cells; IC50 = 8.6 ± 0.3 ng/ml for Co12, human colon cancer cells). Prompted by the high potency of cancer cell growth inhibition, additional action mechanism studies were performed with antofine. Utilizing cultured Co12 cells as a model, antofine induced arrest in the G2/M phase of the cell cycle after 48 h of incubation. With wash-out experiment, colony formation was also inhibited in a dose-dependent manner. These data suggest the potential of antofine to serve as a cancer chemotherapeutic agent by virtue of arresting the cell cycle. | - |
dc.language | English | - |
dc.title | Cytotoxic activity and G2/M cell cycle arrest mediated by antofine, a phenanthroindolizidine alkaloid isolated from Cynanchum paniculatum | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 69 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 21 | - |
dc.relation.lastpage | 25 | - |
dc.relation.journaltitle | Planta Medica | - |
dc.identifier.doi | 10.1055/s-2003-37021 | - |
dc.identifier.wosid | WOS:000180899300004 | - |
dc.identifier.scopusid | 2-s2.0-0037283273 | - |
dc.author.google | Lee S.K. | - |
dc.author.google | Nam K.-A. | - |
dc.author.google | Heo Y.-H. | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |