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Synthesis and antifungal activity of 6,7-Bis-[S-(aryl)thio]-5,8- quinolinediones

Title
Synthesis and antifungal activity of 6,7-Bis-[S-(aryl)thio]-5,8- quinolinediones
Authors
Ryu C.-K.Sun Y.-J.Shim J.-Y.You H.-J.Ko U.C.Lee H.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2002
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 25, no. 6, pp. 795 - 800
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
6,7-Bis-[S-(aryl)thio]-5,8-quinolinediones 4 and 5 were synthesized by the substitution of 6,7-dichloro-5,8-quinolinediones with appropriate arylthiols. Their antifungal activity were tested in vitro for their growth inhibitory activities against pathogenic fungi in comparison with flucytosine. The antifungal activities were significantly improved by S-(aryl)thio moieties of the compounds 4 and 5. The all tested compounds 4 and 5 showed generally good activities against C. albicans and A. niger ranging from 0.8 to 25 μg/ml. Among them, compounds 4d-4h and 5a-5c exhibited also good activities against C. krusei and C. tropicalis. The activities of compounds 4j and 4l were comparable to those of flucytosine against all tested fungi.
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약학대학 > 약학과 > Journal papers
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