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Synthesis and MMP-inhibitory activity of gelastatin analogues

Title
Synthesis and MMP-inhibitory activity of gelastatin analogues
Authors
Cho J.-H.Ko S.Y.Oh E.Park J.C.Yoo J.U.
Ewha Authors
고수영
SCOPUS Author ID
고수영scopus
Issue Date
2002
Journal Title
Helvetica Chimica Acta
ISSN
0018-019XJCR Link
Citation
vol. 85, no. 11, pp. 3994 - 3999
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Gelastatin A and B, isolated from culture broth of Westerdykella multispora F 50733, have been reported to exhibit MMP-inhibitory activities at a sub-micromolar level. In an effort to exploit this lead, we synthesized gelastatin analogues in which the conjugated triene unit of natural gelastatins was replaced by the benzylidene group. The (Z)-isomeric synthetic benzylidene-gelastatin exhibited MMP-inhibitory activities comparable to those reported for the natural products. Therefore, this compound appears to be a viable lead in searching for therapeutically useful MMP inhibitors.
DOI
10.1002/1522-2675(200211)85:11&lt3994::AID-HLCA3994&gt3.0.CO2-2
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자연과학대학 > 화학·나노과학전공 > Journal papers
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