Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고수영 | - |
dc.date.accessioned | 2016-08-28T11:08:10Z | - |
dc.date.available | 2016-08-28T11:08:10Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0018-019X | - |
dc.identifier.other | OAK-1275 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219112 | - |
dc.description.abstract | Gelastatin A and B, isolated from culture broth of Westerdykella multispora F 50733, have been reported to exhibit MMP-inhibitory activities at a sub-micromolar level. In an effort to exploit this lead, we synthesized gelastatin analogues in which the conjugated triene unit of natural gelastatins was replaced by the benzylidene group. The (Z)-isomeric synthetic benzylidene-gelastatin exhibited MMP-inhibitory activities comparable to those reported for the natural products. Therefore, this compound appears to be a viable lead in searching for therapeutically useful MMP inhibitors. | - |
dc.language | English | - |
dc.title | Synthesis and MMP-inhibitory activity of gelastatin analogues | - |
dc.type | Article | - |
dc.relation.issue | 11 | - |
dc.relation.volume | 85 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 3994 | - |
dc.relation.lastpage | 3999 | - |
dc.relation.journaltitle | Helvetica Chimica Acta | - |
dc.identifier.doi | 10.1002/1522-2675(200211)85:11< | - |
dc.identifier.doi | 3994::AID-HLCA3994> | - |
dc.identifier.doi | 3.0.CO | - |
dc.identifier.doi | 2-2 | - |
dc.identifier.wosid | WOS:000179932000032 | - |
dc.identifier.scopusid | 2-s2.0-0036940204 | - |
dc.author.google | Cho J.-H. | - |
dc.author.google | Ko S.Y. | - |
dc.author.google | Oh E. | - |
dc.author.google | Park J.C. | - |
dc.author.google | Yoo J.U. | - |
dc.contributor.scopusid | 고수영(7403325351) | - |
dc.date.modifydate | 20230208103927 | - |