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Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase

Title
Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase
Authors
Lee H.-T.Yang S.-W.Kyeong H.K.Seo E.-K.Mar W.
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2002
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 25, no. 2, pp. 151 - 153
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Three pseudoguaianolide type sesquiterpenes, bigelovin (1), 2,3-dihydroaromaticin (2), and ergolide (3) were isolated as inhibitory constituents against inducible nitric oxide synthase (iNOS) from the flowers of Inula britannica var. chinensis. Bigelovin (1) exhibited a highly potent inhibitory activity on lipopolysaccharide (LPS)-induced iNOS in murine macrophage RAW 264.7 cells with an IC50 value of 0.46 mM, which is about 8 times more potent than the known selective inhibitor of iNOS, L- N 6-(1-iminoethyl)lysine (IC50 3.49 μM). 2,3-Dihydroaromaticin (2) and ergolide (3) also exhibited potent inhibitory activities on LPS-induced iNOS with IC50 values of 1.05 and 0.69 μM, respectively.
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약학대학 > 약학과 > Journal papers
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