Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-28T11:08:57Z | - |
dc.date.available | 2016-08-28T11:08:57Z | - |
dc.date.issued | 2002 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-1023 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218977 | - |
dc.description.abstract | Three pseudoguaianolide type sesquiterpenes, bigelovin (1), 2,3-dihydroaromaticin (2), and ergolide (3) were isolated as inhibitory constituents against inducible nitric oxide synthase (iNOS) from the flowers of Inula britannica var. chinensis. Bigelovin (1) exhibited a highly potent inhibitory activity on lipopolysaccharide (LPS)-induced iNOS in murine macrophage RAW 264.7 cells with an IC50 value of 0.46 mM, which is about 8 times more potent than the known selective inhibitor of iNOS, L- N 6-(1-iminoethyl)lysine (IC50 3.49 μM). 2,3-Dihydroaromaticin (2) and ergolide (3) also exhibited potent inhibitory activities on LPS-induced iNOS with IC50 values of 1.05 and 0.69 μM, respectively. | * |
dc.language | English | * |
dc.title | Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 25 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 151 | * |
dc.relation.lastpage | 153 | * |
dc.relation.journaltitle | Archives of Pharmacal Research | * |
dc.identifier.wosid | WOS:000175217800004 | * |
dc.identifier.scopusid | 2-s2.0-0036545562 | * |
dc.author.google | Lee H.-T. | * |
dc.author.google | Yang S.-W. | * |
dc.author.google | Kyeong H.K. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Mar W. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |