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Structure-activity relationships of apio nucleosides as potential antiviral agents

Title
Structure-activity relationships of apio nucleosides as potential antiviral agents
Authors
Jeong L.S.Moon H.R.Hong J.H.Yoo S.J.Choi W.J.Kim H.O.Ahn H.S.Baek H.W.Chun M.W.Kim H.-D.Kim J.Choi J.-R.
Ewha Authors
정낙신
Issue Date
2001
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
vol. 20, no. 4-7, pp. 657 - 660
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.
DOI
10.1081/NCN-100002344
Appears in Collections:
약학대학 > 약학과 > Journal papers
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