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Lysophosphatidylcholine derived from deer antler extract suppresses hyphal transition in Candida albicans through MAP kinase pathway

Title
Lysophosphatidylcholine derived from deer antler extract suppresses hyphal transition in Candida albicans through MAP kinase pathway
Authors
Min J.Lee Y.-J.Kim Y.-A.Park H.-S.Han S.-Y.Jhon G.-J.Choi W.
Ewha Authors
전길자최원자한소엽
SCOPUS Author ID
전길자scopus; 최원자scopus; 한소엽scopus
Issue Date
2001
Journal Title
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
ISSN
1388-1981JCR Link
Citation
vol. 1531, no. 1-2, pp. 77 - 89
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A family of 2-lysophosphatidylcholines (lyso-PCs) was isolated from deer antler extract, guided exclusively by hyphal transition inhibitory activity in Candida albicans. Structural determination of the isolated lyso-PCs by spectroscopic methods, including infrared spectroscopy, 1H nuclear magnetic resonance (NMR), 13C NMR, 2D correlation spectroscopy NMR, fast atom bombardment mass spectrometry and tandem mass spectrometry, confirmed that the natural products were composed of at least four different lyso-PCs varying in fatty acid moiety at the sn-1 position of the glycerol backbone. The major lyso-PCs were confirmed as 1-stearoyl-, 1-oleoyl-, 1-linoleoyl- and 1-palmitoyl-2-lyso-sn-glycero-3-phosphatidylcholines. Lyso-PC specifically suppressed the morphogenic transition from yeast to hyphae in C. albicans, without affecting the growth of either yeast or hyphae. Lyso-PC exerted hyphal transition that suppressed activity in the broad spectrum of the Candida species, such as C. albicans, Candida krusei, Candida guilliermondii and Candida parapsilosis. Northern analysis indicated that the suppression was mediated through the mitogen-activated protein kinase pathway. © 2001 Elsevier Science B.V.
DOI
10.1016/S1388-1981(01)00088-9
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자연과학대학 > 화학·나노과학전공 > Journal papers
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