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dc.contributor.author전길자-
dc.contributor.author최원자-
dc.contributor.author한소엽-
dc.date.accessioned2016-08-28T11:08:39Z-
dc.date.available2016-08-28T11:08:39Z-
dc.date.issued2001-
dc.identifier.issn1388-1981-
dc.identifier.otherOAK-659-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/218773-
dc.description.abstractA family of 2-lysophosphatidylcholines (lyso-PCs) was isolated from deer antler extract, guided exclusively by hyphal transition inhibitory activity in Candida albicans. Structural determination of the isolated lyso-PCs by spectroscopic methods, including infrared spectroscopy, 1H nuclear magnetic resonance (NMR), 13C NMR, 2D correlation spectroscopy NMR, fast atom bombardment mass spectrometry and tandem mass spectrometry, confirmed that the natural products were composed of at least four different lyso-PCs varying in fatty acid moiety at the sn-1 position of the glycerol backbone. The major lyso-PCs were confirmed as 1-stearoyl-, 1-oleoyl-, 1-linoleoyl- and 1-palmitoyl-2-lyso-sn-glycero-3-phosphatidylcholines. Lyso-PC specifically suppressed the morphogenic transition from yeast to hyphae in C. albicans, without affecting the growth of either yeast or hyphae. Lyso-PC exerted hyphal transition that suppressed activity in the broad spectrum of the Candida species, such as C. albicans, Candida krusei, Candida guilliermondii and Candida parapsilosis. Northern analysis indicated that the suppression was mediated through the mitogen-activated protein kinase pathway. © 2001 Elsevier Science B.V.-
dc.languageEnglish-
dc.titleLysophosphatidylcholine derived from deer antler extract suppresses hyphal transition in Candida albicans through MAP kinase pathway-
dc.typeArticle-
dc.relation.issue1-2-
dc.relation.volume1531-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage77-
dc.relation.lastpage89-
dc.relation.journaltitleBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids-
dc.identifier.doi10.1016/S1388-1981(01)00088-9-
dc.identifier.wosidWOS:000167942300006-
dc.identifier.scopusid2-s2.0-0035970789-
dc.author.googleMin J.-
dc.author.googleLee Y.-J.-
dc.author.googleKim Y.-A.-
dc.author.googlePark H.-S.-
dc.author.googleHan S.-Y.-
dc.author.googleJhon G.-J.-
dc.author.googleChoi W.-
dc.contributor.scopusid전길자(6701488476)-
dc.contributor.scopusid최원자(7402515987)-
dc.contributor.scopusid한소엽(7405944194)-
dc.date.modifydate20191108081000-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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