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Stereoselective determination of cetirizine and studies on pharmacokinetics in rat plasma

Title
Stereoselective determination of cetirizine and studies on pharmacokinetics in rat plasma
Authors
Choi S.O.Lee S.H.Kong H.S.Kim E.J.Choo H.-Y.P.
Ewha Authors
박혜영
SCOPUS Author ID
박혜영scopus
Issue Date
2000
Journal Title
Journal of Chromatography B: Biomedical Sciences and Applications
ISSN
1387-2273JCR Link
Citation
vol. 744, no. 1, pp. 201 - 206
Indexed
SCOPUS WOS scopus
Abstract
Enantiomers may confer benefits over racemates in therapeutic uses and we developed a chiral separation method of cetirizine enantiomers, a second generation H1 histamine receptor antagonist, in rat plasma. α1-Acidglycoprotein based chiral stationary phase(AGP-CSP), monitored with UV at 230 nm was used to separate the enantiomers. Observed enantioselectivity (α) was 2.0. The AGP-CSP was also used at a preparative scale to isolate the enantiomers with an optical purity of greater than ee 99%. In addition, an analysis was carried out for the cetirizine enantiomers in rat plasma to study the differences of enantiomers in pharmacokinetics. Both (+)- and (-)-cetirizine were separated using a reversed-phase column of AGP, and were detected at the range of 2.5-200 μgml-1 in plasma. Although there was no recognizable differences in pharmacokinetics between the enantiomers in rat, the method appears to be useful for their pharmacokinetic studies. Copyright (C) 2000 Elsevier Science B.V.
DOI
10.1016/S0378-4347(00)00229-2
Appears in Collections:
약학대학 > 약학과 > Journal papers
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